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Fosinopril is an angiotensin converting enzyme (ACE) inhibitor which is used in the treatment of mild to moderate essential hypertension and in the management of symptomatic congestive heart failure.
Following oral administration, fosinopril is rapidly hydrolyzed to fosinoprilat, its principal active metabolite.

Generic Monopril is used for treating high blood pressure (hypertension) or heart failure. Both of these are long term (chronic) diseases so it is important that you continue to take your Monopril every day.

Active Ingredients: Fosinopril sodium
Other Ingredients : anhydrous lactose, microcrystalline cellulose, crospovidone, povidone and sodium stearyl fumarate.
Class and Mechanism: Fosinopril sodium belongs to a class of medicines known as ACE inhibitors. It works by widening your blood vessels, reducing the pressure in the vessels (reducing 'blood pressure') and by making it easier for your heart to pump blood around your body. This helps your heart to work better by increasing the supply of oxygen to your heart. Your doctor may have prescribed Monopril for another reason. Ask your doctor if you have any questions about why Monopril has been prescribed for you.

Keep your tablets in the blister pack until it is time to take them. If you take the tablets out of the pack they will not keep well. Keep Monopril tablets in a cool dry place, in the dark ,where the temperature stays between 15 and 30 degrees C (59 and 86 degrees F). Do not store Monopril or any other medicine in the bathroom or near a sink. Do not leave it in the car on hot days or on window sills. Heat and dampness can destroy some medicines. Keep it where children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.

Follow all directions given to you by your doctor or pharmacist carefully. Monopril is usually taken at a dose of 10mg to 40mg once a day. Your doctor may have prescribed a different dose for you. Take Monopril at about the same time each day. Taking your tablet at about the same time each day will help you to remember when to take it. It does not matter if you take Monopril before or after food. If you need to take an antacid, take it at least 2 hours before or two hours after your dose of Monopril.
If OVERDOSE is suspected, contact your local poison control center or emergency room immediately. Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention. Any medication taken in excess can have serious consequences.

If you forget to take one or more doses of Monopril, take your next dose at the normal time and in the normal amount. Do not take a double dose to make up for the dose that you missed. Do not take any more than your doctor prescribed for you.

Be careful the first time you take Monopril, especially if you are elderly. Be careful driving or operating machinery until you know how Monopril affects you. As with other ACE inhibitor medicines, Monopril may cause dizziness, or light-headedness in some people. Make sure you know how you react to Monopril before you drive a car, operate machinery,or do anything else that could be dangerous if you are dizzy or light-headed. If this occurs do not drive.
If you drink alcohol, dizziness or light-headedness may be worse.

Do not take Monopril if:
• you have an allergy to fosinopril sodium (the active ingredient in Monopril), or to any of the inactive ingredients listed in the “Generic Monopril Drug Interactions” section.
  Symptoms of an allergic reaction to Monopril may include skin ash, itchiness, and shortness of breath, swelling of the face, lips or tongue, muscle pain or tenderness or joint pain.
• you have taken any other 'ACE inhibitor' medicine before, which caused your face, lips, tongue, throat, hands or feet to swell up or made it hard for you to breathe.
  If you have had an allergic reaction to an ACE inhibitor medicine before, you may be allergic to Monopril.
• you have a history of angioedema or angioneurotic oedema, which is swelling of the face, lips, tongue, throat (which may cause difficulty in swallowing or breathing), hands or feet, for no apparent reason.
• Do not take Monopril if you are pregnant. Monopril adversely affects your developing baby if you take it during pregnancy.
• Do not take Monopril if you are breastfeeding or intend to breastfeed.
• Do not take Monopril after the expiry date printed on the pack.
• Do not take Monopril if the packaging is torn or shows signs of tampering.
• Do not take Monopril if the tablets change in appearance, color or taste.

If you are not sure whether you should start taking Monopril, talk to your doctor.

As with other ACE inhibitor medicines, you may feel light-headed or dizzy when you begin to take Monopril or after your dose is increased. This is because your blood pressure is dropping suddenly. If you feel light-headed, dizzy or faint when getting out of bed or standing up, get up slowly. Standing up slowly, especially when you get up from bed or chairs, will help your body get used to the change in position and blood pressure.
Monopril helps most people with high blood pressure, but it may have unwanted side effects in a few people. All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects. Ask your doctor or pharmacist to answer any questions you may have.
Following is a list of possible side effects. Do not be alarmed by this list. You may not experience any of them.

Tell your doctor or pharmacist if you notice any of the following and they worry you:
• feeling lightheaded, dizzy or faint
• headache
• tiredness, fatigue or weakness
• dry cough
• feeling sick (nausea) or vomiting
• upset stomach (dyspepsia) or heartburn
• diarrhoea
• stomach pains
• muscle cramps or pains

These are the more common side effects of MONOPRIL. (Mostly these are mild and short lived). Tell your doctor as soon as possible if you notice any of the following:
• changes to your heart rhythm
• infections of your urinary tract or upper respiratory tract (URTI, or cold or flu symptoms)
• severe dizziness (vertigo)
• impotence (inability to get or maintain an erection)
• mild rash or itching
• gout (painful, swollen joints)
• diabetes (symptoms include - excessive thirst, greatly increased amount of urine, increase of appetite with a loss of weight, feeling tired, drowsy, weak, depressed, irritable and generally unwell)
• sore throat and fever
• hepatitis (symptoms include - nausea, vomiting, loss of appetite, feeling generally unwell, fever, itching, yellowing of the skin and eyes and dark coloured urine)
• confusion; irregular heartbeat; nervousness; numbness or tingling of the hands, feet or lips; shortness of breath or difficulty breathing; weakness or heaviness of legs. (You may experience these symptoms if too much potassium builds up in your body.)

These are serious side effects. You may need medical attention. Serious side effects are rare. If any of the following happen you should stop taking Monopril and call your doctor immediately or go to Accident and Emergency at your nearest hospital:
Swollen face, swollen lips, swollen mouth, swollen throat, swollen hands or feet; if you faint or if your skin turns yellow; sore throat and fever; chest pain; difficulty breathing; itchy skin and/or rash; or not urinating (passing water) as much as usual. These are very serious side effects.
You may need urgent medical attention or hospitalization.
Other side effects not listed above may occur in some patients. Tell your doctor or pharmacist if you notice anything that is making you feel unwell.
Do not be alarmed by this list of possible side effects.
You may not experience any of them

Tell your doctor or pharmacist if you are taking any other medicines, including any that you buy without a prescription from your pharmacy, supermarket or health food shop.

Some medicines can affect the way Monopril works. It is especially important that you tell your doctor if you are taking any of the following:
• water tablets or diuretics (for example Lasix(R), Urex(R), Natrilix(R), Moduretic(R))
• lithium or lithium-containing preparations (for example Lithicarb(R), Priadel(R))
• potassium tablets (for example SPAN-K(R), SLOW-K(R) or MAG-K(R))
• potassium-containing salt substitutes (for example PRESSOR-K(R))
• antacids
• arthritis/osteoarthritis medicines which are called non-steroidal anti-inflammatory drugs (NSAIDS) (for example Voltaren(R), Indocid(R))
• if you are taking Monopril for high blood pressure do not take any medicine (including ones bought without prescription) for appetite control, asthma, colds, coughs, hayfever or sinus problems unless you have discussed the medicine with your doctor or pharmacist.

These medicines may be affected by Monopril, or may affect how well it works. You may need different amounts of your medicine or you may need to take different medicines. Your doctor will advise you. Your doctor and pharmacist may have more information on medicines to be careful with or avoid while taking Monopril.

Do not give Monopril to anyone else, even if they have the same condition as you.
Do not take Monopril to treat any other complaints unless your doctor or pharmacist tells you to.
Do not stop taking Monopril, or lower the dosage, without checking with your doctor.
Have your blood pressure checked when your doctor says, to make sure Monopril is working.
Go to your doctor regularly for a check-up.
Make sure you drink enough water during exercise and hot weather when you are taking Monopril, especially if you sweat a lot.
If you do not drink enough water while taking Monopril, your blood pressure may drop suddenly and you may dehydrate. If you experience any of the above symptoms, tell your doctor.
If you plan to have surgery that needs a general anaesthetic, tell your doctor or dentist that you are taking Monopril.
Having a general anesthetic while taking Monopril may also cause your blood pressure to drop suddenly.
If you become pregnant while taking Monopril, tell your doctor immediately.
If you are about to have blood tests, tell your doctor that you are taking Monopril.
Monopril may interfere with the results of some tests.